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1822810-13-8

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1822810-13-8 Structure

1822810-13-8 Structure

Identification	Back Directory
[Name] tert-Butyl 4-(((benzyloxy)carbonyl)amino)-5-methyl-3-oxohexanoate
[CAS] 1822810-13-8
[Synonyms] tert-Butyl 4-(((benzyloxy)carbonyl)amino)-5-methyl-3-oxohexanoate Hexanoic acid, 5-methyl-3-oxo-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester
[Molecular Formula] C19H27NO5
[MOL File] 1822810-13-8.mol
[Molecular Weight] 349.42

Chemical Properties	Back Directory
[Boiling point ] 464.4±35.0 °C(Predicted)
[density ] 1.100±0.06 g/cm3(Predicted)
[pka] 10.10±0.46(Predicted)

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[Uses] Monomethyl auristatin E intermediate-5 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
[References] [1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931

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