| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-(sulfooxy)- | [CAS]
182322-62-9 | [Synonyms]
4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-(sulfooxy)- | [Molecular Formula]
C15H10O8S | [MOL File]
182322-62-9.mol | [Molecular Weight]
350.3 |
| Hazard Information | Back Directory | [Uses]
Genistein 7-Sulfate Sodium Salt is a derivative of Genistein (446-72-0). Genistein exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol. | [Definition]
ChEBI: Genistein 7-sulfate is a member of isoflavones. |
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