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182495-83-6

182495-83-6 Structure

182495-83-6 Structure
IdentificationBack Directory
[Name]

N-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite
[CAS]

182495-83-6
[Synonyms]

DMT-2'-F-dC(Bz)-CE-Phosphoramidite
2’-Fluoro-5MeC (Bz)-3’-phosphoramidite
N-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite
N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite
N4-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-2’-fluoro-5-methylcytidine-3’-O-[(2-cyanoethyl) (N,N-diisopropyl)]phosphoramidite
Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
2’-Fluoro-5MeC(Bz)-3’-phosphoramidite,N4-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-2’-fluoro-5-methylcytidine-3’-O-[(2-cyanoethyl) ,(N,N-diisopropyl)]phosphoramidite
[Molecular Formula]

C47H53FN5O8P
[MDL Number]

MFCD34548945
[MOL File]

182495-83-6.mol
[Molecular Weight]

865.94
Chemical PropertiesBack Directory
[solubility ]

DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
[pka]

8.52±0.40(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319
[Precautionary statements ]

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard InformationBack Directory
[Uses]

DMT-2'-F-dC(Bz)-CE-Phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
[References]

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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