| Identification | Back Directory | [Name]
Benzenemethanamine, N-[(2-fluorophenyl)methyl]-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-, hydrochloride (1:2) | [CAS]
1825455-91-1 | [Synonyms]
Benzenemethanamine, N-[(2-fluorophenyl)methyl]-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-, hydrochloride (1:2) | [Molecular Formula]
C21H19ClFN3 | [MOL File]
1825455-91-1.mol | [Molecular Weight]
367.85 |
| Hazard Information | Back Directory | [Uses]
OXA-06 hydrochloride is an ATP-competitive ROCK inhibitor that blocks anchorage-dependent growth and invasion of non-small cell lung cancer cell lines. OXA-06 hydrochloride inhibits cofilin phosphorylation but does not stimulate apoptosis[1]. | [Biological Activity]
OXA 06 dihydrochloride is a potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro. | [storage]
Desiccate at RT | [References]
[1] Vigil D, et al. ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 2012 Oct 15;72(20):5338-47. DOI:10.1158/0008-5472.CAN-11-2373 |
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