| Identification | Back Directory | [Name]
Urea, N-[2-chloro-7-[(1R)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- | [CAS]
1832577-07-7 | [Synonyms]
(R)-MLT-985
Urea, N-[2-chloro-7-[(1R)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- | [Molecular Formula]
C17H15Cl2N9O2 | [MOL File]
1832577-07-7.mol | [Molecular Weight]
448.27 |
| Hazard Information | Back Directory | [Uses]
(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells[1]. | [References]
[1] Jean Quancard, et al. Optimization of the?In Vivo?Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608. DOI:10.1021/acs.jmedchem.0c01246 |
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