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1832671-96-1

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1832671-96-1 Structure

1832671-96-1 Structure
IdentificationBack Directory
[Name]

Y06036
[CAS]

1832671-96-1
[Synonyms]

Y06036
Benzenesulfonamide, 5-bromo-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzisoxazol-5-yl)-
[Molecular Formula]

C16H15BrN2O5S
[MDL Number]

MFCD31813647
[MOL File]

1832671-96-1.mol
[Molecular Weight]

427.27
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 130 mg/mL (304.26 mM)
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Y06036 is CRPC inhibitor.
[in vivo]

Y06036 (50 mg/kg, i.p. injection, 5 times per week, 25 days) demonstrates therapeutic effects in a C4-2B CRPC xenograft tumor model in mice. Y06036 is well tolerated in the treated mice, based on the weight of the animal body and their general behavior[1].

Animal Model:Four-week-old male mice (strain: C.B-17/IcrHsd-Prkdcscid for C4-2B) with C4-2B mouse xenograft model[1]
Dosage:50 mg/kg, 100 μL
Administration:Intraperitoneal (i.p.) injection, 5 times per week, 25 days
Result:Exhibited strong antitumor activities during the 25-day treatment period, with a tumor growth inhibition (TGI) of 70%.
[IC 50]

BRD4(1): 82 nM (Kd)
Spectrum DetailBack Directory
[Spectrum Detail]

Y06036(1832671-96-1)1HNMR
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