| Identification | Back Directory | [Name]
(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid | [CAS]
1832713-02-6 | [Synonyms]
RA 839
(S)-1-(4-((2,3,5,6-Tetramethylphenyl)sulfonamido)naphthalen-1-yl)pyrrolidine-3-carboxylic acid
(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
3-Pyrrolidinecarboxylic acid, 1-[4-[[(2,3,5,6-tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-, (3S)- | [Molecular Formula]
C25H28N2O4S | [MOL File]
1832713-02-6.mol | [Molecular Weight]
452.57 |
| Chemical Properties | Back Directory | [Boiling point ]
707.9±70.0 °C(Predicted) | [density ]
1.313±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.04±0.30(Predicted) | [color ]
Pale Brown to Light Brown |
| Hazard Information | Back Directory | [Uses]
RA 839 is a noncovalent small molecule binder to Keap1 and a selective activator of Nrf2 signaling. | [Biological Activity]
RA839 is an active in vivohighly selective and potent activator of Nrf2 (transcription factor NF-E2-related factor 2) signaling. RA839 binds noncovalently to the Nrf2-interacting kelch domain of Keap1 thereby inhibiting the interaction between Keap1 and Nrf2. RA839 inhibits the induction of both inducible nitric oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA-839 is a potent antagonist of Rotavirus propagation in vitro th at inhibits viral RNA and protein expression. | [in vivo]
RA839 (30 mg/kg, i.p.) modulates Nrf2 target genes in the context of reduced oxidative liver metabolism in mice, inducing hepatic mRNA levels of the prototypic Nrf2 target genes GCLC and NQO1[1].
| [storage]
Store at +4°C |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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