| Chemical Properties | Back Directory | [Boiling point ]
650.7±55.0 °C(Predicted) | [density ]
1.033±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
An oil | [pka]
5.21±0.33(Predicted) |
| Hazard Information | Back Directory | [Description]
IT-143B is a bacterial metabolite that has been found in S. iakyrus.1 It inhibits the proliferation of OS-RC-2 and ACHN cancer cells (IC50s = 22 and 98 μM, respectively). | [Uses]
IT-143B is an antibiotic, that exhibits antibacterial activity against Micrococcus luteus with MIC of 6.25μg/mL. IT-143B inhibits growth of cancer cell KB with an IC50 of 1.1 ng/mL[1]. | [References]
1. Li, K., Liang, Z., Chen, W., et al. Iakyricidins A-D, antiproliferative piericidin analogues bearing a carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104 J. Org. Chem. 84(19),12626-12631(2019). |
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