| Identification | Back Directory | [Name]
t-Butoxycarbonyl-PEG4-NHS ester | [CAS]
1835759-75-5 | [Synonyms]
OtBu-PEG4-SPA
CAS_1835759-75-5
Boc-PEG4-C2-NHS ester
NHS ester-PEG3-t-butyl ester
t-Butoxycarbonyl-PEG4-NHS ester
4,7,10,13-Tetraoxahexadecanedioic acid, 1-(1,1-dimethylethyl) 16-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C20H33NO10 | [MDL Number]
MFCD29052203 | [MOL File]
1835759-75-5.mol | [Molecular Weight]
447.477 |
| Hazard Information | Back Directory | [Description]
t-Butoxycarbonyl-PEG4-NHS ester has a t-Boc protecting group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
Boc-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Henan Alfachem Co.,Ltd.
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