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1835759-88-0

1835759-88-0 Structure

1835759-88-0 Structure
IdentificationBack Directory
[Name]

Azido-PEG1-methylamine
[CAS]

1835759-88-0
[Synonyms]

Azido-PEG1-methylamine
Azido-PEG1-C2-methylamine
2-(2-Azidoethoxy)-N-methylethanamine
2-(2-azidoethoxy)-N-methylethanamine HCl
[Molecular Formula]

C5H12N4O
[MDL Number]

MFCD29042337
[MOL File]

1835759-88-0.mol
[Molecular Weight]

144.18
Hazard InformationBack Directory
[Description]

Azido-PEG1-methylamine contain an azide group and methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
[Uses]

Azido-PEG1-C2-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-C2-methylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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