| Identification | Back Directory | [Name]
Ald-PEG5-Azide | [CAS]
1446282-38-7 | [Synonyms]
CHO-PEG5-azide
Ald-PEG5-Azide
N3-PEG5-CH2CHO
Ald-CH2-PEG5-N3
ALD-CH2-PEG5-AZIDE | [Molecular Formula]
C12H23N3O6 | [MDL Number]
MFCD25424111 | [MOL File]
1446282-38-7.mol | [Molecular Weight]
305.33 |
| Hazard Information | Back Directory | [Description]
Ald-CH2-PEG5-azide is a click chemistry crosslinker containing an azide group and an aldehyde group. The azide group enables PEGylation via Click Chemistry. PEG5 arm increases solubility in aqueous media. The aldehyde group reacts with amines and the N-terminal of peptides and proteins to form an imine containing a C=N double bond, which can be further reduced. | [Uses]
Ald-CH2-PEG5-azide is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Ald-CH2-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [Biological Activity]
Ald-CH2-PEG5-azide is a non-cleavable ADC linker containing 5-unit PEG that can be used to synthesize antibody drug conjugates (ADCs). | [target]
| [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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