| Identification | More | [Name]
2-Amino-3-(trifluoromethyl)pyridine | [CAS]
183610-70-0 | [Synonyms]
2-AMINO-3-(TRIFLUOROMETHYL)PYRIDINE
3-(TRIFLUOROMETHYL)-2-PYRIDINAMINE
3-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE | [EINECS(EC#)]
623-444-2 | [Molecular Formula]
C6H5F3N2 | [MDL Number]
MFCD04972538 | [Molecular Weight]
162.11 | [MOL File]
183610-70-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
70-72°C | [Boiling point ]
203.2±35.0 °C(Predicted) | [density ]
1.368±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
4.18±0.36(Predicted) | [color ]
Off-white | [InChIKey]
YWOWJQMFMXHLQD-UHFFFAOYSA-N | [CAS DataBase Reference]
183610-70-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
2-?Amino-?3-?(trifluoromethyl)?pyridine is a reagent used in the preparation of novel propanamide derivatives functioning as fatty acid amide inhibitors. | [Synthesis]
The general procedure for the synthesis of 2-amino-3-trifluoromethylpyridine from 2-fluoro-3-trifluoromethylpyridine was as follows: 750 g of 2-fluoro-3-trifluoromethylpyridine and 700 g of water were added sequentially to an ammonia reactor, followed by the slow addition of 250 g of liquid ammonia. The reaction system was heated up to 130 °C, and the reaction pressure was maintained at a set value for 10 hours. Upon completion of the reaction, the system was cooled to 90 °C and the reaction mixture was transferred to a receiving kettle. After further cooling to 10 °C, the solid product was obtained by centrifugation and dried to obtain 2-amino-3-trifluoromethylpyridine in about 95% yield. | [References]
[1] Patent: CN108003093, 2018, A. Location in patent: Paragraph 0008; 0017-0018; 0020-0021; 0023-0024 |
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