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1837-91-8

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1837-91-8 Structure

1837-91-8 Structure
IdentificationMore
[Name]

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
[CAS]

1837-91-8
[Synonyms]

NSC 7908
JAK2 INHIBITOR II
BENZENE HEXABROMIDE
trans-α-Benzene hexabromide
1,2,3,4,5,6-Hexabromcyclohexan
1,2,3,4,5,6-hexabromo-cyclohexan
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
Cyclohexane, 1,2,3,4,5,6-hexabromo-
JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem
[Molecular Formula]

C6H6Br6
[MDL Number]

MFCD00059127
[Molecular Weight]

557.54
[MOL File]

1837-91-8.mol
Chemical PropertiesBack Directory
[Melting point ]

218.0 to 223.0 °C
[storage temp. ]

Store at RT
[solubility ]

DMSO: soluble2mg/mL (clear solution, warmed)
[form ]

powder
[color ]

white to beige
[InChI]

1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
[InChIKey]

QFQZKISCBJKVHI-UHFFFAOYSA-N
[SMILES]

BrC1C(C(C(C(C1Br)Br)Br)Br)Br
[CAS DataBase Reference]

1837-91-8(CAS DataBase Reference)
[EPA Substance Registry System]

Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[WGK Germany ]

3
[TSCA ]

Yes
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Acute Tox. 4 Oral
Eye Irrit. 2
Hazard InformationBack Directory
[Uses]

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.
[Definition]

ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.
[Biological Activity]

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)MS
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)IR1
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)IR2
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)Raman
Well-known Reagent Company Product InformationBack Directory
[TCI AMERICA]

1,2,3,4,5,6-Hexabromocyclohexane(1837-91-8)
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