| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)-, hydrochloride (1:1) | [CAS]
183849-45-8 | [Synonyms]
Abaperidone Hydrochloride
4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)-, hydrochloride (1:1) | [Molecular Formula]
C25H26ClFN2O5 | [MOL File]
183849-45-8.mol | [Molecular Weight]
488.94 |
| Hazard Information | Back Directory | [Description]
Abaperidone, also known as FI 8602, is an antipsychotic. Reduced hsp70 in the prefrontal cortex may play a critical role in the etiology of many schizophrenia symptoms and may be linked to an atypical profile of antipsychotics, such as abaperidone. | [Uses]
Abaperidone hydrochloride is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. | [References]
[1] Bolós J, et al. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. DOI:10.1021/jm9810396 |
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