| Identification | Back Directory | [Name]
NNC 05-2090 hydrochloride | [CAS]
184845-18-9 | [Synonyms]
NNC 05 2090 hydrochloride,NNC 052090 hydrochloride | [Molecular Formula]
C27H31ClN2O2 | [MOL File]
184845-18-9.mol | [Molecular Weight]
451.01 |
| Hazard Information | Back Directory | [Uses]
NNC 05-2090 Hydrochloride is a GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters. | [in vivo]
NNC 05-2090 hydrochloride (intraperitoneal injection) dose-dependently protects against maximal electroshock (MES) in mice with an ED50 values of 73 μmol/kg, and shows ED50 values against tonic and clonic convulsions in DBA/2 mice of 19 and 26 μmol /kg, respectively[1].
NNC 05-2090 hydrochloride (0.01, 0.1 and 0.3 mg/kg; i.p. or i.,t., once) reverses mechanical allodynia in (partial sciatic nerve ligation) PSL model mice[3]. | Animal Model: | Partial sciatic nerve ligation (PSL) mice with mechanical allodynia[2] | | Dosage: | 0.01, 0.1 and 0.3 mg/kg | | Administration: | Intraperitoneal injection or intrathecal injection; 0.1 mg/kg, once | | Result: | Dose-dependently reversed mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection. |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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