| Identification | Back Directory | [Name]
IRAK4-IN-4 | [CAS]
1850276-58-2 | [Synonyms]
IRAK4-IN-4
1,2-Ethanedione, 1-(7-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-phenyl- | [Molecular Formula]
C22H16N2O2 | [MDL Number]
MFCD32671362 | [MOL File]
1850276-58-2.mol | [Molecular Weight]
340.37 |
| Chemical Properties | Back Directory | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mg/mL (73.45 mM) | [form ]
Solid | [pka]
3.01±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM[1]. | [References]
[1] One class has the naphthalene second dione compounds and its derivative of protease modification activities. CN107163044A. |
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