| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2369751-07-3 | [Synonyms]
G140
pegcetacoplan(APL-2)，G140
Inhibitor,cGAS,anti-inflammatory,G 140,Cyclic GMP-AMP Synthase,G140,synthase,G-140,GMP-AMP,cyclic,inhibit
Ethanone, 1-[6,7-dichloro-1,3,4,5-tetrahydro-9-(1-methyl-1H-pyrazol-3-yl)-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy- | [Molecular Formula]
C17H16Cl2N4O2 | [MOL File]
2369751-07-3.mol | [Molecular Weight]
379.24 |
| Chemical Properties | Back Directory | [Boiling point ]
663.1±55.0 °C(Predicted) | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (659.21 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.47±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0?nM and 442?nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1]. | [Biological Activity]
Substrate site-targetingnon-cytotoxicpotent and selective human cyclic GMP-AMP synthase (cGAS) inhibitor against cellular STING signaling. | [storage]
Store at -20°C | [References]
[1] Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261. DOI:10.1038/s41467-019-08620-4 |
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