| Identification | Back Directory | [Name]
QC6352 | [CAS]
1851373-36-8 | [Synonyms]
QC6352
CPD1548
QC-6352,QC6352
4-Pyridinecarboxylic acid, 3-[[[(1R)-1,2,3,4-tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]- | [Molecular Formula]
C24H25N3O2 | [MDL Number]
MFCD31630821 | [MOL File]
1851373-36-8.mol | [Molecular Weight]
387.47 |
| Chemical Properties | Back Directory | [Boiling point ]
681.6±55.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 25 mg/mL (64.52 mM) | [form ]
Solid | [pka]
1.55±0.36(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
3-[[[(1R)-1,2,3,4-Tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-Pyridinecarboxylic Acid is also known as a KDM4 inhibitor exhibiting antiproliferative effects in cancer models. | [in vivo]
QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2]. | [IC 50]
KDM4; KDM5B: 750 nM (IC50); KDM4A: 104 nM (IC50); KDM4B: 56 nM (IC50); KDM4C: 35 nM (IC50); KDM4D: 104 nM (IC50) |
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