| Identification | Back Directory | [Name]
ChiMMitecan | [CAS]
185425-25-6 | [Synonyms]
ChiMMitecan
PubChem ID: 11603813
9-Allyl-10-Hydroxycamptothecin
(S)-10-allyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione | [Molecular Formula]
C23H20N2O5 | [MDL Number]
MFCD28138424 | [MOL File]
185425-25-6.mol | [Molecular Weight]
404.42 |
| Chemical Properties | Back Directory | [Boiling point ]
803.0±65.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.25±0.40(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C23H20N2O5/c1-3-5-13-14-8-12-10-25-18(20(12)24-17(14)6-7-19(13)26)9-16-15(21(25)27)11-30-22(28)23(16,29)4-2/h3,6-9,26,29H,1,4-5,10-11H2,2H3/t23-/m0/s1 | [InChIKey]
AXXPNDLHTNUMIK-QHCPKHFHSA-N | [SMILES]
N1C2C(=C(CC=C)C(O)=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O |
| Hazard Information | Back Directory | [Uses]
Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1]. | [References]
[1] Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13(4):1298-307. DOI:10.1158/1078-0432.CCR-06-1277 |
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| Company Name: |
Abydos Scientific
|
| Tel: |
025-84767922 18936879710 |
| Website: |
www.abydoscientific.com/index.html |
| Company Name: |
Cool Pharm, Ltd
|
| Tel: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
|