185425-25-6

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185425-25-6 Structure

Identification	Back Directory
[Name] ChiMMitecan
[CAS] 185425-25-6
[Synonyms] ChiMMitecan PubChem ID: 11603813 9-Allyl-10-Hydroxycamptothecin (S)-10-allyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
[Molecular Formula] C23H20N2O5
[MDL Number] MFCD28138424
[MOL File] 185425-25-6.mol
[Molecular Weight] 404.42

Chemical Properties	Back Directory
[Boiling point ] 803.0±65.0 °C(Predicted)
[density ] 1.49±0.1 g/cm3(Predicted)
[form ] Solid
[pka] 9.25±0.40(Predicted)
[color ] Light yellow to yellow
[InChI] InChI=1S/C23H20N2O5/c1-3-5-13-14-8-12-10-25-18(20(12)24-17(14)6-7-19(13)26)9-16-15(21(25)27)11-30-22(28)23(16,29)4-2/h3,6-9,26,29H,1,4-5,10-11H2,2H3/t23-/m0/s1
[InChIKey] AXXPNDLHTNUMIK-QHCPKHFHSA-N
[SMILES] N1C2C(=C(CC=C)C(O)=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O

Hazard Information	Back Directory
[Uses] Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].
[References] [1] Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13(4):1298-307. DOI:10.1158/1078-0432.CCR-06-1277

Spectrum Detail	Back Directory
[Spectrum Detail] ChiMMitecan(185425-25-6)¹HNMR

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