| Chemical Properties | Back Directory | [Boiling point ]
1127.383±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.068±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Chloroform: Soluble
Ethanol: Soluble | [form ]
Liquid | [pka]
9.329±0.50(predicted) | [color ]
Colorless to light yellow | [InChIKey]
HMIDEMNFLBUNTB-UHFFFAOYSA-N | [SMILES]
N(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC |
| Hazard Information | Back Directory | [Uses]
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model[1]. | [in vivo]
4A3-SC8 mediates siRNA accumulation mainly in liver and slightly in the spleen and kidneys 24 hours after intravenous injection at dosage of 1 mg siRNA/kg and enables >95% FVII knockdown in mice[1].
After injection with 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), mice became sick and lost nearly 20% of their weight on the first day postinjection[1]. | [References]
[1] Zhou K, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5. DOI:10.1073/pnas.1520756113 |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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