| Chemical Properties | Back Directory | [Boiling point ]
1038.9±65.0 °C(Predicted) | [density ]
1.088±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol: 10 mg/ml | [form ]
Liquid | [pka]
9.23±0.50(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA[1]. | [in vivo]
306-O12B is a leading tail-branched bioreducible lipidoid. 306-O12B lipid nanoparticle (LNP) specifically delivered Cas9 mRNA and sgAngptl3 to liver hepatocytes of wild-type C57BL/6 mice, resulting in a median editing rate of 38.5% and a corresponding 65.2% reduction of serum ANGPTL3 protein[1]. | [References]
[1] Qiu M, Glass Z, Chen J, et al. Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of?Angptl3.?Proc Natl Acad Sci U S A. 2021;118(10):e2020401118. DOI:10.1073/pnas.2020401118 |
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| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
nanjing
|
| Tel: |
13376084917 13376082704 |
| Website: |
www.linye-e.com/ |
|