| Identification | Back Directory | [Name]
CPUY201112 | [CAS]
1860793-58-3 | [Synonyms]
CPUY201112 Methanone, [2,4-dihydroxy-5-(1-methylethyl)phenyl](2-ethoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)- | [Molecular Formula]
C19H23N3O4 | [MOL File]
1860793-58-3.mol | [Molecular Weight]
357.4 |
| Hazard Information | Back Directory | [Uses]
CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1]. | [in vivo]
CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) inhibits tumor growth in the MCF-7 tumor xenograft model[1].
| Animal Model: | Female BALB/c nude mice with MCF-7 cell[1] | | Dosage: | 5 mg/kg, 20 mg/kg and 40 mg/kg | | Administration: | i.p., daily, 3 weeks | | Result: | Reduced tumor volume by 11.92%, 26.58% and 39.63%, respectively, when using 5 mg/kg, 20 mg/kg and 40 mg/kg.
Significantly induced the expression of Hsp70 and reduced the expression of Akt at 40 mg/kg. |
| [References]
[1] Xiao-Li X, et al. CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells. Sci Rep. 2016 Jan 8;6:19004. DOI:10.1038/srep19004 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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