ChemicalBook--->CAS DataBase List--->1860793-58-3

1860793-58-3

1860793-58-3 Structure

1860793-58-3 Structure
IdentificationBack Directory
[Name]

CPUY201112
[CAS]

1860793-58-3
[Synonyms]

CPUY201112
Methanone, [2,4-dihydroxy-5-(1-methylethyl)phenyl](2-ethoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-
[Molecular Formula]

C19H23N3O4
[MOL File]

1860793-58-3.mol
[Molecular Weight]

357.4
Chemical PropertiesBack Directory
[Boiling point ]

603.8±65.0 °C(Predicted)
[density ]

1.284±0.06 g/cm3(Predicted)
[pka]

8.37±0.48(Predicted)
Hazard InformationBack Directory
[Uses]

CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1].
[in vivo]

CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) inhibits tumor growth in the MCF-7 tumor xenograft model[1].

Animal Model:Female BALB/c nude mice with MCF-7 cell[1]
Dosage:5 mg/kg, 20 mg/kg and 40 mg/kg
Administration:i.p., daily, 3 weeks
Result:Reduced tumor volume by 11.92%, 26.58% and 39.63%, respectively, when using 5 mg/kg, 20 mg/kg and 40 mg/kg.
Significantly induced the expression of Hsp70 and reduced the expression of Akt at 40 mg/kg.
[References]

[1] Xiao-Li X, et al. CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells. Sci Rep. 2016 Jan 8;6:19004. DOI:10.1038/srep19004
1860793-58-3 suppliers list
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Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd  
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