| Identification | Back Directory | [Name]
2-Thiazolidinethione, 4-hydroxy-4-phenyl-3-(4-pyridinylmethyl)- | [CAS]
1862177-86-3 | [Synonyms]
COB-187
2-Thiazolidinethione, 4-hydroxy-4-phenyl-3-(4-pyridinylmethyl)- | [Molecular Formula]
C15H14N2OS2 | [MOL File]
1862177-86-3.mol | [Molecular Weight]
302.41 |
| Chemical Properties | Back Directory | [Boiling point ]
515.4±60.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.85±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys)-199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production[1]. | [IC 50]
GSK-3β | [References]
[1] Mehrani R, et al. Capturing the Effects of Single Atom Substitutions on the Inhibition Efficiency of Glycogen Synthase Kinase-3β Inhibitors via Markov State Modeling and Experiments. J Chem Theory Comput. 2024 Jul 8. DOI:10.1021/acs.jctc.4c00311 |
|
|