186611-11-0

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186611-11-0 Structure

Identification	Back Directory
[Name] su5204
[CAS] 186611-11-0
[Synonyms] 2H-Indol-2-one, 3-[(2-ethoxyphenyl)methylene]-1,3-dihydro-
[Molecular Formula] C17H15NO2
[MDL Number] MFCD04651331
[MOL File] 186611-11-0.mol
[Molecular Weight] 265.31

Chemical Properties	Back Directory
[Boiling point ] 476.9±45.0 °C(Predicted)
[density ] 1.209±0.06 g/cm3(Predicted)
[storage temp. ] Sealed in dry,2-8°C
[solubility ] DMSO: 100 mg/mL (376.92 mM)
[form ] Solid
[pka] 12.82±0.20(Predicted)
[color ] Light yellow to yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H315-H319-H335
[Precautionary statements ] P261-P305+P351+P338

Hazard Information	Back Directory
[Uses] SU5204, a tyrosine kinase inhibitor, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively[1].
[IC 50] VEGFR2: 4 μM (IC₅₀); HER2: 51.5 μM (IC₅₀)
[References] [1] Peng Cho Tang, et al. 3-heteroaryl-2-indolinone compounds for the treatment of disease. US5792783A.

Spectrum Detail	Back Directory
[Spectrum Detail] su5204(186611-11-0)¹HNMR

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