| Identification | Back Directory | [Name]
CXCR2-IN-1 | [CAS]
1873376-49-8 | [Synonyms]
CXCR2-IN-1
CXCR2 inhibitor 1
N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea
Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]- | [Molecular Formula]
C19H20Cl2FN3O4S | [MDL Number]
MFCD31382127 | [MOL File]
1873376-49-8.mol | [Molecular Weight]
476.35 |
| Chemical Properties | Back Directory | [Boiling point ]
538.1±50.0 °C(Predicted) | [density ]
1.528±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 5.4 mg/mL (11.34 mM) | [form ]
Solid | [pka]
5.02±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
N-(2-Chloro-3-fluorophenyl)-N''-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea is a CNS penetrant CXCR2 antagonist. | [in vivo]
CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1]. | [IC 50]
CXCR2: 9.3 (pIC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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https://www.bocsci.com |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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