1873376-49-8
中文名称
1873376-49-8
英文名称
CXCR2-IN-1
CAS
1873376-49-8
分子式
C19H20Cl2FN3O4S
分子量
476.35
MOL 文件
1873376-49-8.mol
1873376-49-8 结构式
基本信息
中文别名
化合物 T10905化合物CXCR2-IN-1
英文别名
CXCR2-IN-1CXCR2 inhibitor 1
N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea
Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-
物理化学性质
沸点538.1±50.0 °C(Predicted)
密度1.528±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 5.4 mg/mL (11.34 mM)
酸度系数(pKa)5.02±0.10(Predicted)
形态Solid
颜色White to off-white
1873376-49-8价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-101022 | CXCR2-IN-1 | 1873376-49-8 | 1 mg | 500元 |
| 2025/05/22 | HY-101022 | 1873376-49-8 CXCR2-IN-1 | 1873376-49-8 | 5mg | 900元 |
| 2025/05/22 | HY-101022 | 1873376-49-8 CXCR2-IN-1 | 1873376-49-8 | 10mM * 1mLin DMSO | 940元 |
常见问题列表
生物活性
CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂，pIC50值为9.3。靶点
|
CXCR2 9.3 (pIC 50 ) |
体外研究
CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45).
体内研究
CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.