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1873376-49-8

中文名称 1873376-49-8
英文名称 CXCR2-IN-1
CAS 1873376-49-8
分子式 C19H20Cl2FN3O4S
分子量 476.35
MOL 文件 1873376-49-8.mol
1873376-49-8 结构式 1873376-49-8 结构式

基本信息

中文别名
化合物 T10905
化合物CXCR2-IN-1
英文别名
CXCR2-IN-1
CXCR2 inhibitor 1
N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea
Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-

物理化学性质

沸点538.1±50.0 °C(Predicted)
密度1.528±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 5.4 mg/mL (11.34 mM)
酸度系数(pKa)5.02±0.10(Predicted)
形态Solid
颜色White to off-white
1873376-49-8价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2025/05/22HY-101022CXCR2-IN-11873376-49-81 mg500元
2025/05/22HY-1010221873376-49-8
CXCR2-IN-1
1873376-49-85mg900元
2025/05/22HY-1010221873376-49-8
CXCR2-IN-1
1873376-49-810mM * 1mLin DMSO940元

常见问题列表

生物活性
CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂,pIC50值为9.3。
靶点

CXCR2

9.3 (pIC 50 )

体外研究

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45).

体内研究

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.

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