| Identification | More | [Name]
4-Methoxyphenoxyacetic acid | [CAS]
1877-75-4 | [Synonyms]
4-METHOXYPHENOXYACETIC ACID
AKOS BB/0049
AKOS BBS-00003727
(P-METHOXYPHENOXY)ACETIC ACID
RARECHEM AL BO 0321
(4-methoxyphenoxy)-aceticaci
2-(4-Methoxyphenoxy)acetic acid
Acetic acid, (p-methoxyphenoxy)-
4-Methoxyphenoxyacetic acid, 98+%
4-Methoxyphenyloxyacetic acid | [EINECS(EC#)]
217-513-2 | [Molecular Formula]
C9H10O4 | [MDL Number]
MFCD00014360 | [Molecular Weight]
182.17 | [MOL File]
1877-75-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R44:Risk of explosion if heated under confinement.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29189990 |
| Hazard Information | Back Directory | [Chemical Properties]
BEIGE-BROWN CRYSTALLINE SOLID | [Uses]
2-(4-Methoxyphenoxy)acetic Acid is a useful research chemical, a metabolite of mefexamide in human urine samples. | [Synthesis]
Compounds B1-7 were prepared by similar methods. In the synthesis of B1, monochloroacetic acid (0.04 mol, 3.78 g) was first dissolved in 15 mL of deionized water under stirring and ice bath conditions. Subsequently, 25% NaOH solution was added drop by drop and the pH was adjusted to 9-10 to produce sodium chloroacetate solution. In another vessel, NaOH (0.03 mol, 1.20 g), 15 mL of deionized water, 5 mL of ethanol and phenol (0.04 mol, 3.76 g) were mixed, and the above sodium chloroacetate solution was added slowly with stirring. After addition, stirring was continued for 20 minutes, followed by dropwise addition of sodium chloroacetate solution and the reaction mixture was heated to 105 °C and refluxed for 5 hours. After completion of the reaction, the mixture was cooled to room temperature and acidified with dilute hydrochloric acid to pH 1-2. The precipitate was collected by filtration, washed several times with dilute hydrochloric acid, and after recrystallization and drying in vacuum, the white solid product phenoxyacetic acid (B1) was obtained. | [References]
[1] Synthetic Communications, 1996, vol. 26, # 23, p. 4337 - 4341
[2] Journal of Fluorescence, 2015, vol. 25, # 4, p. 849 - 859
[3] Luminescence, 2018, vol. 33, # 5, p. 855 - 862
[4] Luminescence, 2015, vol. 30, # 5, p. 677 - 685
[5] Journal of Molecular Structure, 2014, vol. 1074, p. 487 - 495 |
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