| Identification | Back Directory | [Name]
3-HYDROXYDODECANOIC ACID | [CAS]
1883-13-2 | [Synonyms]
3-hydroxylauricaci
3-HYDROXY C12:0 ACID
3-HYDROXYDODECANOIC ACID
DL-BETA-HYDROXYLAURIC ACID
Dodecanoic acid,3-hydroxy-
3-Hydroxydodecanoic acid, 98 %
(+/-)-3-HYDROXYDODECANOIC ACID | [Molecular Formula]
C12H24O3 | [MDL Number]
MFCD00133279 | [MOL File]
1883-13-2.mol | [Molecular Weight]
216.32 |
| Chemical Properties | Back Directory | [Melting point ]
70-70.5 °C | [Boiling point ]
113-115 °C(Press: 3 Torr) | [density ]
0.987±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.38±0.10(Predicted) | [color ]
Pale Beige to Light Beige | [InChI]
InChI=1S/C12H24O3/c1-2-3-4-5-6-7-8-9-11(13)10-12(14)15/h11,13H,2-10H2,1H3,(H,14,15) | [InChIKey]
MUCMKTPAZLSKTL-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CC(O)CCCCCCCCC | [LogP]
3.110 (est) |
| Hazard Information | Back Directory | [Uses]
3-hydroxydodecanoic acid is used in the study of Lipid A, a major constituent of the lipopolysaccharides, which are responsible for the toxicity of gram negative bacteria. Also used in the synthesis of olefins from β-hydroxy carboxylic acids.
| [Definition]
ChEBI: A medium-chain fatty acid that is the 3-hydroxylated derivative of lauric acid; associated with fatty acid metabolic disorders. | [Biochem/physiol Actions]
DL-3-Hydroxydodecanoic acid (3HDD) is a racemic mixture of D- and L-3HDD. 3-hydroxydodecanoic acid is found as a monomer in the construction of polyhydroxyalkanoates. 3HDD is used to study the roles of β-hydroxy fatty acids in chronic inflammation and insulin resistance and the biosynthesis of diffusible signal factors involved in quorum sensing. | [in vivo]
3-Hydroxydodecanoic acid (i.p., days 6, 9, and 12) shows anti-tumor effect via GPR84 activation and IL-12 production in mice carrying MC38 tumors[2].
. | Animal Model: | C57BL/6JRj mice carrying MC38 tumors[2] | | Dosage: | | | Administration: | Intraperitoneal injection (i.p.), days 6, 9, and 12 | | Result: | Showed a significant reduction in tumor growth.
Increased IL-12.
Exhibited higher infiltration of CD8+ T cells in tumors.
Was dependent on GPR84 receptor signaling.
Had a strong anti-tumor effect in combination with 5-FU.
|
| [IC 50]
Human Endogenous Metabolite |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|