| Identification | Back Directory | [Name]
2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- | [CAS]
1883431-67-1 | [Synonyms]
2,5-Piperazinedione, 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]- | [Molecular Formula]
C84H152N4O6 | [MOL File]
1883431-67-1.mol | [Molecular Weight]
1314.13 |
| Chemical Properties | Back Directory | [Boiling point ]
1159.0±65.0 °C(Predicted) | [density ]
0.954±0.06 g/cm3(Predicted) | [solubility ]
Ethanol: 10 mg/ml | [form ]
Oil | [pka]
12.87±0.60(Predicted) | [color ]
Colorless to light yellow | [InChIKey]
UMSCHHWDFWCONK-RGLFHLPNSA-N | [SMILES]
N1C(CCCCN(CC(O)CCCCCC/C=C\C/C=C\CCCCC)CC(O)CCCCCC/C=C\C/C=C\CCCCC)C(=O)NC(CCCCN(CC(O)CCCCCC/C=C\C/C=C\CCCCC)CC(O)CCCCCC/C=C\C/C=C\CCCCC)C1=O |
| Hazard Information | Back Directory | [Description]
OF-02 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 LNPs containing OF-02 localize to the liver after intravenous administration in mice. Intravenous administration of LNPs containing OF-02 and encapsulating human erythropoietin (EPO) mRNA increases serum EPO levels in mice. | [Uses]
OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery. | [References]
1. Fenton, O.S., Kauffman, K.J., McClellan, R.L., et al. Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery Adv. Mater. 28(15),2939-2943(2016). |
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