| Identification | Back Directory | [Name]
2'-C-ethynyluridine | [CAS]
188413-98-1 | [Synonyms]
EOS-61194
2'-C-ethynyluridine
Uridine, 2'-C-ethynyl-
2'-beta-C-Ethynyluridine
1-((2R,3R,4R,5R)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | [Molecular Formula]
C11H12N2O6 | [MOL File]
188413-98-1.mol | [Molecular Weight]
268.22 |
| Hazard Information | Back Directory | [Uses]
2'-C-Ethynyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2'-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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