| Identification | Back Directory | [Name]
Urea, N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]- | [CAS]
1884461-72-6 | [Synonyms]
Ensifentrine
Ensifentrina
Ensifentrinum
Ensifentrine ( RPL554 )
EnsifentrineQ: What is
Ensifentrine Q: What is the CAS Number of
Ensifentrine
Urea, N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-
RPL 554,RPL554,inhaled,Inhibitor,RPL-554,Ensifentrine,bronchoprotective,inhibit,COPD,PDE4,anti-inflammatory,PDE3,Phosphodiesterase (PDE) | [Molecular Formula]
C26H31N5O4 | [MOL File]
1884461-72-6.mol | [Molecular Weight]
477.56 |
| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (52.35 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.73±0.46(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
RPL 554 is a known drug candidate for respiratory diseases, particularly in patients with asthma or chronic obstructive pulmonary diseases. | [in vivo]
Ensifentrine (RPL-554; 10 mg/kg; Oral administration; once) significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs[1].
The inhalation of dry powder containing Ensifentrine by conscious guinea pigs (25% in micronized lactose) 1.5 h before antigen exposure significantly inhibits the recruitment of eosinophils to the airways[1].
Exposure of conscious guinea pigs to inhalation of dry powder containing Ensifentrine (2.5%) in micronized lactose significantly inhibits histamine-induced plasma protein extravasation in the trachea and histamine-induced bronchoconstriction over a 5.5-h period[1]. | Animal Model: | Male Dunkin Hartley guinea pigs (200-300 g) injected with ovalbumin[1]. | | Dosage: | 10 mg/kg
| | Administration: | Oral administration; once | | Result: | Significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs. |
| [IC 50]
PDE3: 0.4 nM (IC50); PDE4: 1479 nM (IC50) |
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