| Identification | Back Directory | [Name]
Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- | [CAS]
1885900-35-5 | [Synonyms]
MT189
Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- | [Molecular Formula]
C21H18FN3O2 | [MOL File]
1885900-35-5.mol | [Molecular Weight]
363.39 |
| Chemical Properties | Back Directory | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : ≥ 100 mg/mL (275.19 mM) | [form ]
Solid | [pka]
8.66±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1]. | [References]
[1] An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372. DOI:10.1016/j.ejmech.2016.02.004 |
|
|