| Identification | Back Directory | [Name]
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE | [CAS]
188640-63-3 | [Synonyms]
p-Ethynylphenylalanine hydrochloride
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE | [Molecular Formula]
C11H12ClNO2 | [MDL Number]
MFCD20259693 | [MOL File]
188640-63-3.mol | [Molecular Weight]
225.671 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Methanol: 125 mg/mL (553.91 mM); DMSO: 100 mg/mL (443.12 mM) | [form ]
Solid | [color ]
Off-white to light yellow | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Uses]
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
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p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase[1].
| Animal Model: | Male Sprague-Dawley rats (200 g)[1] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
| [References]
[1] Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. DOI:10.1046/j.1471-4159.2000.0742067.x |
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