188640-63-3
中文名称
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE
英文名称
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE
CAS
188640-63-3
分子式
C11H12ClNO2
分子量
225.671
MOL 文件
188640-63-3.mol
188640-63-3 结构式
基本信息
中文别名
化合物P-ETHYNYLPHENYLALANINE HYDROCHLORIDE 英文别名
p-Ethynylphenylalanine hydrochloride4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE
物理化学性质
储存条件-20°C储存
溶解度Methanol: 125 mg/mL (553.91 mM); DMSO: 100 mg/mL (443.12 mM)
形态Solid
颜色Off-white to light yellow
水溶解性Water: < 0.1 mg/mL (insoluble)
4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-23460A | 4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE p-Ethynylphenylalanine hydrochloride | 188640-63-3 | 50mg | 800元 |
| 2025/05/22 | HY-23460A | 4-ETHYNYL-L-PHENYLALANINE HYDROCHLORIDE p-Ethynylphenylalanine hydrochloride | 188640-63-3 | 10mM * 1mLin DMSO | 880元 |
常见问题列表
生物活性
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 Ki 值为 32.6 μM。靶点
Ki: 32.6 μM (TPH)
体外研究
p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
体内研究
p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase.
| Animal Model: | Male Sprague-Dawley rats (200 g) |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |