| Identification | Back Directory | [Name]
4-Nitrophenyl 2-(pyridin-2-yldisulfanyl)propyl carbonate | [CAS]
1887040-81-4 | [Synonyms]
PPC-NB
4-Nitrophenyl 2-(pyridin-2-yldisulfanyl)propyl carbonate
Carbonic acid, 4-nitrophenyl 2-(2-pyridinyldithio)propyl ester | [Molecular Formula]
C15H14N2O5S2 | [MDL Number]
MFCD28556921 | [MOL File]
1887040-81-4.mol | [Molecular Weight]
366.41 |
| Chemical Properties | Back Directory | [Boiling point ]
529.2±50.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [form ]
Liquid | [pka]
1.69±0.19(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
PPC-NB is a glutathione cleavable linker used for the antibody-drug conjugate (ADC)[1]. | [IC 50]
Disulfide Cleavable Linker | [References]
[1] Robert A. Volkmann, et al. Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues. WO2019136298A1. |
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