| Identification | Back Directory | [Name]
2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate | [CAS]
1956318-90-3 | [Synonyms]
PDdEC-NB
2-methyl-2-(pyridin-2-yldisulfanyl)propyl 4-nitrophenyl carbonate
Carbonic acid, 2-methyl-2-(2-pyridinyldithio)propyl 4-nitrophenyl ester | [Molecular Formula]
C16H16N2O5S2 | [MDL Number]
MFCD28556917 | [MOL File]
1956318-90-3.mol | [Molecular Weight]
380.44 |
| Chemical Properties | Back Directory | [Boiling point ]
531.9±50.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
1.73±0.19(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PDdEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC). | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Flygare, John, et al. Anthracycline disulfide intermediates, antibody-?drug conjugates and methods.WO?2016040825?A1?20160317. |
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