| Identification | Back Directory | [Name]
whi-p131hydrochloride dihydrate | [CAS]
188829-39-2 | [Synonyms]
WHI-P131 hydrochloride hydrate
whi-p131hydrochloride dihydrate
WHI-P131 hydrate hydrochloride
4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline hydrochloride
4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline hydrochloride
4-(4′-Hydroxylphenyl)-amino-6,7-dimethoxyquinazoline hydrochloride hydrate
4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline hydrochloride dihydrate
JANEX-1, 4-(4μ-Hydroxylphenyl)-amino-6,7-dimethoxyquinazoline hydrate hydrochloride | [Molecular Formula]
C16H16ClN3O3 | [MDL Number]
MFCD11045992 | [MOL File]
188829-39-2.mol | [Molecular Weight]
333.77 |
| Hazard Information | Back Directory | [Uses]
JANEX-1 (WHI-P131) hydrochloride is a potent and specific JAK3 inhibitor (Ki=2.3 μM). JANEX-1 hydrochloride shows potent JAK3 inhibitory activity (IC50=78 μM), does not inhibit JAK1 and JAK2[1][2][3][4]. | [IC 50]
JAK3: 78 μM (IC50) | [References]
[1] Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. PMID:10389946
[2] Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23 DOI:10.1038/emm.2013.43
[3] Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62. PMID:10537365
[4] Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14(3):450-464. DOI:10.1080/15548627.2017.1421884 |
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