| Identification | Back Directory | [Name]
N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride | [CAS]
189061-11-8 | [Synonyms]
N-(4-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)BUTYL)-9H-FLUORENE-2-CARBOXAMIDE HCL | [Molecular Formula]
C28H30Cl3N3O | [MDL Number]
MFCD09971107 | [MOL File]
189061-11-8.mol | [Molecular Weight]
530.916 |
| Hazard Information | Back Directory | [Uses]
NGB 2904 Hydrochloride is a dopamine D3 receptor antagonist that inhibits cocaine’s rewarding effects and cocaine-induced reinstatement of drug seeking behavior in rats. | [Biological Activity]
Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.''NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for r at and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine. | [in vivo]
NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice[3].
NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice[3]. | [IC 50]
D3 Receptor: 1.4 (Ki) | [storage]
-20°C |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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R&D Systems, Inc
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18003437475 18003437475 |
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www.rndsystems.com |
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