| Identification | Back Directory | [Name]
CP 154526 | [CAS]
257639-98-8 | [Synonyms]
CP-154526 Hydrochloride
N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine monohydrochloride
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-butyl-N-ethyl-2,5-diMethyl-7-(2,4,6-triMethylphenyl)-, (Hydrochloride) (1:1) | [Molecular Formula]
C23H33ClN4 | [MDL Number]
MFCD07364047 | [MOL File]
257639-98-8.mol | [Molecular Weight]
400.988 |
| Chemical Properties | Back Directory | [Melting point ]
167-169°C | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChI]
1S/C23H32N4.ClH/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5;/h12-14H,8-11H2,1-7H3;1H | [InChIKey]
ZWDLBNCJWNENFF-UHFFFAOYSA-N | [SMILES]
Cl.CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c3c(C)cc(C)cc3C |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. | [Uses]
CP-154526 Hydrochloride is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1) (1,2,3). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF and displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. | [Biochem/physiol Actions]
CP-154526 is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). | [in vivo]
CP 154526 (1-10 mg/kg; i.p.; once) hydrochloride exhibits signs of anxiolytic-like activity in the elevated plus-maze test in rats[2]. | Animal Model: | Male Sprague Dawley rats[2] | | Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg | | Administration: | i.p.; once | | Result: | Exhibited signs of anxiolytic-like activity. |
| [storage]
Desiccate at +4°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|