| Identification | Back Directory | [Name]
L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- | [CAS]
18921-73-8 | [Synonyms]
861
Ccnsc529
SK 29861
SK-29861
Ccnsc-529
Ccnsc 529
Chlorasquin
Ccnsc529,861
Ccnsc-529,861
Ccnsc 529,861
L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- | [Molecular Formula]
C20H19ClN6O5 | [MDL Number]
MFCD01664838 | [MOL File]
18921-73-8.mol | [Molecular Weight]
458.86 |
| Hazard Information | Back Directory | [Uses]
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents[1][2]. | [References]
[1] Chello PL, et al. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res. 1976 Jul;36(7 PT 1):2442-9. PMID:1277151
[2] Hynes J B, et al. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids[J]. Journal of Medicinal Chemistry, 1977, 20(4): 588-591. DOI:10.1021/jm00214a030 |
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