| Identification | Back Directory | [Name]
Thiol-dPEG4-t-boc-N-amido | [CAS]
1895922-68-5 | [Synonyms]
Thiol-PEG3-NHBoc
BocNH-PEG3-CH2CH2SH
Boc-N-amido-PEG3-thiol
t-Boc-N-amido-PEG3-thiol
Thiol-dPEG4-t-boc-N-amido
5,8,11-Trioxa-2-azatridecanoic acid, 13-mercapto-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H27NO5S | [MOL File]
1895922-68-5.mol | [Molecular Weight]
309.42 |
| Hazard Information | Back Directory | [Description]
t-Boc-N-amido-PEG3-thiol is a PEG derivative containing a Boc-protected amino group and a thiol group. The Boc group can be deprotected under mild acidic conditions to form the free amine. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. | [Uses]
Thiol-PEG3-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. DOI:10.1016/j.chembiol.2020.07.020 |
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