| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG7-propargyl | [CAS]
2112737-90-1 | [Synonyms]
Propargyl-PEG7-NHBoc
Boc-NH-PEG7-propargyl
t-Boc-N-Amido-PEG7-propargyl
tert-Butyl 3,6,9,12,15,18,21-heptaoxatetracos-23-yn-1-ylcarbamate | [Molecular Formula]
C22H41NO9 | [MDL Number]
MFCD30828698 | [MOL File]
2112737-90-1.mol | [Molecular Weight]
463.56 |
| Chemical Properties | Back Directory | [Boiling point ]
532.7±50.0 °C(Predicted) | [density ]
1.072±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG7-propargyl is a crosslinking reagent that enables the formation of triazole linkage with azides under the catalyzation of copper. The Boc-protected amine can be deprotected under mild acidic conditions. By introducing PEG chain into the molecule, the hydrophilicity can be greatly improved. | [Uses]
Boc-NH-PEG7-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG7-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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