| Identification | Back Directory | [Name]
H2N-PEG3-CH2COOtBu | [CAS]
189808-70-6 | [Synonyms]
NH2-PEG3-C1-Boc
H2N-PEG3-CH2COOtBu
NH2-PEG3-CH2COOtBu
Amino-PEG3-CH2COOtBu
Amino-peg3-butyl ester
Amino-PEG3-CH2CO2-t-butyl ester
tert-Butyl 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)acetate
Acetic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C12H25NO5 | [MDL Number]
MFCD30730374 | [MOL File]
189808-70-6.mol | [Molecular Weight]
263.33 |
| Chemical Properties | Back Directory | [Boiling point ]
343.4±27.0 °C(Predicted) | [density ]
1.041±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Amino-PEG3-CH2CO2-t-butyl ester is a PEG molecule containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group (t-Boc) can be deprotected under acidic conditions. | [Uses]
NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
|
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|