| Identification | Back Directory | [Name]
H2N-PEG11-CH2CH2COOH | [CAS]
1616426-12-0 | [Synonyms]
Amino-PEG11-COOH
Amino-PEG11-acid
H2N-PEG11-CH2CH2COOH
Amino-PEG11-propionic acid | [Molecular Formula]
C25H51NO13 | [MOL File]
1616426-12-0.mol | [Molecular Weight]
573.67 |
| Chemical Properties | Back Directory | [Boiling point ]
637.6±55.0 °C(Predicted) | [density ]
1.125±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.28±0.10(Predicted) | [color ]
Light green to green |
| Hazard Information | Back Directory | [Uses]
Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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