| Identification | Back Directory | [Name]
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER | [CAS]
191102-87-1 | [Synonyms]
GGTI-2147
GGTI-2147
(GGTI2147)
TUQRZGWNDBXSNP-SANMLTNESA-N
Geranylgeranyl transferase inhibitor-2147
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester | [Molecular Formula]
C28H30N4O3 | [MDL Number]
MFCD22581512 | [MOL File]
191102-87-1.mol | [Molecular Weight]
470.56 |
| Chemical Properties | Back Directory | [Boiling point ]
710.6±60.0 °C(Predicted) | [density ]
1.224±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.22±0.46(Predicted) | [color ]
off-white | [Sensitive ]
Light Sensitive & Hygroscopic | [InChIKey]
TUQRZGWNDBXSNP-SANMLTNESA-N | [SMILES]
[nH]1cnc(c1)CNc2cc(c(cc2)C(=O)N[C@@H](CC(C)C)C(=O)OC)c3c4c(ccc3)cccc4 |
| Hazard Information | Back Directory | [Uses]
GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells. | [Biological Activity]
Cell permeable: yes''Primary Target
GGTase-I''Product does not compete with ATP.''Reversible: no''Target IC50: 500 nM in blocking the geranyl-geranylation of Rap1A |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|