| Identification | Back Directory | [Name]
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide | [CAS]
1917294-46-2 | [Synonyms]
PF4745637
PF-4745637
PF 4745637
PF-04745637
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide | [Molecular Formula]
C27H32ClF3N2O2 | [MDL Number]
MFCD31617910 | [MOL File]
1917294-46-2.mol | [Molecular Weight]
509.003 |
| Chemical Properties | Back Directory | [Boiling point ]
651.8±55.0 °C(Predicted) | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.14±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1]. | [Biological Activity]
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].
Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1]. | [in vivo]
Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1]. | [IC 50]
TRPA1: 17 nM (IC50) | [References]
[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809. |
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