| Identification | Back Directory | [Name]
N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri
din-4-yl)benzoyl]piperidine-3-carboxamide | [CAS]
1922098-90-5 | [Synonyms]
CCG257081
CCG-257081
CCG 257081
N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri
din-4-yl)benzoyl]piperidine-3-carboxamide | [Molecular Formula]
C24H19ClF3N3O2 | [MDL Number]
MFCD34600840 | [MOL File]
1922098-90-5.mol | [Molecular Weight]
473.87 |
| Chemical Properties | Back Directory | [Boiling point ]
689.1±55.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.69±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
CCG-257081 is an inihibitor of Rho/MRTF/SRF pathway. CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models. | [Uses]
MRTF/SRF-IN-1 (example 41) is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis[1]. | [References]
[1] Larsen Scott D, et al. Preparation of substituted piperidine-3-carboxamides as inhibitors of myocardin-related transcription factor and serum response factor (MTRF/SRF)-mediated gene transcription. World Intellectual Property Organization, WO2016073847 A2. 2016-05-12. |
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