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193620-69-8

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193620-69-8 Structure

193620-69-8 Structure
IdentificationBack Directory
[Name]

TAS-301
[CAS]

193620-69-8
[Synonyms]

CS-1543
TAS 301.TAS301
TAS-301;TAS 301.TAS301
3-[bis(4-methoxyphenyl)methylidene]-1H-indol-2-one
3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one,3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-
[Molecular Formula]

C23H19NO3
[MDL Number]

MFCD05865245
[MOL File]

193620-69-8.mol
[Molecular Weight]

357.4
Chemical PropertiesBack Directory
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO: 40 mg/mL
[form ]

solid
[color ]

Light yellow to yellow
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

TAS 301 is an inhibitor of smooth muscle cell migration and proliferation. It blocks voltage-independent calcium influx and downstream PKC signaling. It also inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery.
[Definition]

ChEBI: 3-[bis(4-methoxyphenyl)methylidene]-1H-indol-2-one is a diarylmethane.
[in vivo]

TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury[2].

[IC 50]

PKC
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

TAS-301(193620-69-8)1HNMR
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