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733030-01-8

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733030-01-8 Structure

733030-01-8 Structure
IdentificationBack Directory
[Name]

TAS-102
[CAS]

733030-01-8
[Synonyms]

TAS-102
TAS 102 (2:1)
TAS102; TAS 102
TAS-102 (LONSURF)
TAS-102(TIPIRACIL, TRIFLURIDINE)
Trifluridine-tipiracil hydrochloride mixt.
Tipiracil hydrochloride-trifluridine mixt.
TRIFLURIDINE-TIPIRACIL HYDROCHLORIDE MIXTURE
TAS-102(Tipiracil hydrochloride-trifluridine mixt)
[Molecular Formula]

C19H23Cl2F3N6O7
[MDL Number]

MFCD30481309
[MOL File]

733030-01-8.mol
[Molecular Weight]

575.323
Chemical PropertiesBack Directory
[Melting point ]

170-172°C
[storage temp. ]

Hygroscopic, Refrigerator, under inert atmosphere
[solubility ]

DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
[Stability:]

Hygroscopic
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)
GHS08
[Signal word ]

Warning
[Hazard statements ]

H341-H351-H361d
[Precautionary statements ]

P201-P308+P313
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Carc. 2
Muta. 2
Repr. 2
Hazard InformationBack Directory
[Uses]

TAS 102 (Tipiracil-trifluridine) is a thymidine phosphorylase inhibitor used in chemotherapy treatment of advanced/recurring colorectal cancer.
[Biological Activity]

Anti cancerAnti angiogenic
[in vivo]

Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2].

Animal Model:Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells[2]
Dosage:150 mg/kg/day
Administration:p.o.; twice a day for 14 days
Result:Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
Spectrum DetailBack Directory
[Spectrum Detail]

TAS-102(733030-01-8)1HNMR
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