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SRI-31142 is a putative allosteric dopamine transporter ligand. | [Uses]
SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine[1]. | [References]
[1] Interactions Between Cocaine and the Putative Allosteric Dopamine Transporter Ligand SRI-31142 |
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